Will the new universal influenza vaccine BPL-1357 test successfully on humans?

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The prediction question will be settled with the outcome of a Phase 1 clinical trial, NCT05027932, tentatively scheduled to complete 1 March 2021.
Reference date: March 1, 2023, 24:00 EST

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Influenza A

Emergency hospital during influenza epidemic, Camp Funston, Kansas. - Copyright: Otis Historical Archives, National Museum of Health and Medicine.Of the four major strains of the influenza virus, A and B cause most human illness and the annual flu epidemics, novel A subtypes can even result in pandemics (e.g. H1N1 for the 1918 flu pandemic) and are responsible for most severe cases and deaths. [1]

The novel vaccine

A new universal vaccine against the influenza A virus was tested successfully on mice and ferrets.  It conferred protection against multiple distinct influenza A strains in mice and ferrets. [2] 

Phase 1 clinical trial

A Phase 1 clinical trial of a candidate vaccine, BPL-1357 has begun inoculating healthy adult volunteers at the National Institutes of Health Clinical Center in Bethesda, Maryland. The placebo-controlled trial will test the safety and its ability to prompt immune responses. [3] It is scheduled to complete on 1 March 2023, and will generate evidence for safety and Immunogenicity against various strains. [4]

Sources

  1. Types of Influenza Viruses. CDC
  2. An inactivated multivalent influenza A virus vaccine. Science, 13 July 2022
  3. Trial of potential universal flu vaccine opens. NIH, 28 June 2022
  4. Safety and Immunogenicity of BPL-1357. ClinicalTrials.gov, 7 July 2022

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Alfie Meier
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Publication is overdue 2023/03/01 24:00 EST